Overview | Teddy New (Tildipirosin) is a new type of animal-specific sixteen-membered macrolide semi-synthetic antibiotic. It was first developed by Inteway International Co., Ltd. (IntervetInternationalBV) and is a derivative of tylosin. |
antibacterial mechanism | the mechanism of action of tedioxin, like other macrolide drugs, can bind to the ribosomal 50S subunit of sensitive bacteria, inhibit the synthesis and extension of peptide chains by blocking the transpeptide action and/or mRNA shift, affect the synthesis of bacterial proteins, and further play a bacteriostatic and bactericidal effect. Tediloxin has a special three nitrogen structure, which absorbs more quickly after injection, has a stronger ability to penetrate the outer wall of the bacteria, and has more binding sites with bacterial ribosomal proteins, so that its antibacterial and bactericidal effects are better than ordinary macrolide antibiotics. Stronger. At the same time, its special three nitrogen structure can prolong the effective concentration time of teddioxin in lung tissue and bronchial fluid. |
pharmacokinetics | after a single dose of tedioxin injection into the neck, pigs were injected intramuscularly at a single dose of 4 mg/kg body weight. the peak time Tmax in blood was 23min, the peak concentration Cmax was 1.12 µg/ml, and the elimination half-lives in plasma and lung tissues were 4 d and 7 d respectively. Macrolides have specific target in lung, and the concentration of lung tissue is significantly higher than that of blood drug. The peak concentration of lung tissue reached 4000ng/g after 24 hours of injection, and the peak concentration in bronchial fluid reached 14000ng/g after 5 days, which was 618 times of the drug concentration in blood and had a lasting effect. After 14 days, higher than 1000 ng/g in lung homogenate and continuously higher than 6000 ng/g in bronchial fluid concentration are still highly sensitive to Pasteurella and Haemophilus parasuis. |
use | tedioxin is a broad-spectrum antibacterial drug, which has antibacterial activity against some gram-positive and gram-negative bacteria, and is especially sensitive to pathogenic bacteria that cause respiratory diseases in pigs and cattle, such as actinobacillus pleuropneumoniae, Pasteurella multocida, Boronella bronchiseptica, Haemophilus parasuis, hemolytic Mannheim, histophilic bacteria, etc. |
safety study | regular dose (4~12 mg/kg body weight) of tedioxin has no effect on blood routine and physiological and biochemical indexes of pigs, but 5 times the dose injection may cause heart, liver and kidney damage. The research results of Lin Hong and others also show that the clinically recommended dose is safe, and the clinical use is also safe for cattle; whether it is intravenous or intramuscular injection, tedioxin is safe for dogs; lamb intravenous or subcutaneous injection of tedioxin 4 mg/kg or 6 mg/kg body weight is safe, and it will cause mild itching, dyspnea and cough at the injection site within 2 to 10 days after treatment. |
biological activity | Tildipirosin is a semi-synthetic macrocyclic lipid antibiotic. |